Three days ago at about midnight my upper lip started feeling tingly and numb like a cold sore was forming. I got up and put some cold sore med on it but it felt different than usual. It was like a pea size bubble just left of the center of my lip and the numbness was not that of a cold sore. I had eaten Chinese food for lunch that day and had a feeling that was what was causing it. I didn't take anything and went back to bed. My cat wakes me up at 4:30 a.m. every morning to go outside, so I let her out and my whole lip was numb. I looked in the mirror and my whole top lip was HUGE. I got showered and dressed and had my aunt who lives next door drive me to the emergency room. The doctor on call didn't seem concerned about the Chinese food. He said it was an allergic reaction to my blood pressure medicine. I take Zestoretic 20/25 and I have taken it for over two years. I know I'm not a doctor but I just can't seem to accept that it is my BP med, it has worked so well for me. The Zestoretic has kept my blood pressure stable and I have not had any noticeable side effects from it. They gave me Benadryl and Prednisone(sp?) in the ER and the swelling finally went down by the next morning. The ER doctor told me to stop taking the Zestoretic and he gave me a 7 day sample of Benicar HCT 20/12.5 and told me to see my regular physician within the next three days. I have not seen me regular doctor yet, my appointment is tomorrow. I just wanted to hear from someone who may have experienced this or has some helpful advice on this subject. Also, while I was eating the Chinese food, a piece of the chicken looked really dark, darker than dark meat chicken and I jokingly told my daughter, "That doesn't look like chicken, I wonder if it really is".